CBT was found in a Cochrane review to be the most successful intervention in reducing chest pain severity and frequency. Hypnosis focusing on relaxation and concentration also showed promise but with less supporting trials/evidence. SSRIs were not superior to placebo in improving chest pain symptoms in a meta-analysis of non-cardiac chest pain patients. SNRIs have not been fully tested in this population.

Publication reference : Campbell KA et al. Noncardiac chest pain: a review for the consultation-liaison psychiatrist. Psychosomatics 2017; 58: 252-265
Reference URL: https://pubmed.ncbi.nlm.nih.gov/28196622/
Publication reference : Kisely SR et al. Psychological interventions for symptomatic management of nonspecific chest pain in patients iwth normal coronary anatomy. Cochrane Database Syst Rev 2010 (1): CD004101
Reference URL: https://pubmed.ncbi.nlm.nih.gov/22696339/
Publication reference : Atluri DK et al. Systematic review with metaanalysis: SSRI for noncardiac chest pain. Aliment Pharmacol Ther 2015; 41: 167-76
Reference URL: https://pubmed.ncbi.nlm.nih.gov/25412947/