THe correct answer is B - dexmedetomidine (Precedex). Lorazepam, midazolam, and propofol are not associated with a reduction in ICU delirium incidence. They are actually more likely to contribute to precipitate or perpetuate delirium. Haloperidol is often used to treat ICU delirium. However, in a recent study of in critically ill adults at high risk of delirium, the use of prophylactic haloperidol compared with placebo did not improve delirium incidence or survival at 28 days.
Publication reference : Maldonado JR, Wysong A, van der Starre PJ, et al: Dexmedetomidine and the reduction of post-operative delirium after cardiac surgery. Psychosomatics 50(3):206-217, 2009 19567759.
Reference URL: https://www.ncbi.nlm.nih.gov/pubmed/?term=19567759
Publication reference : Constantin JM, Momon A, Mantz J, et al: Efficacy and safety of sedation with dexmedetomidine in critical care patients: a meta-analysis of randomized controlled trials. Anaesth Crit Care Pain Med 35(1):7-15, 2016 26700947.
Reference URL: https://www.ncbi.nlm.nih.gov/pubmed/?term=26700947
Publication reference : van den Boogaard et al. Effect of Haloperidol on Survival Among Critically Ill Adults With a High Risk of Delirium: The REDUCE Randomized Clinical Trial. JAMA 2018; 319: 680-690.
Reference URL: https://www.ncbi.nlm.nih.gov/pubmed/29466591
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