What is the most common complication to fetus/neonate due to in utero exposure to paroxetine?
The correct answer is A. One study found a 30% risk of withdrawal symptoms in infants of mothers treated with SSRI/SNRI. Due to its short half-life, paroxetine may confer a larger risk of neonatal abstinence syndrome, which most commonly presents with gastrointestinal or sleep disturbance, hypertonicity, and high-pitched cry, with peak symptoms 48hrs after delivery and resolving within 5 days. The prevalence of the other listed complications is considerably lower (and, in the case of autism, controversial as to whether related).
Publication reference : Levinson-Castiel R et al. Neonatal Abstinence Syndrome After In Utero Exposure to Selective Serotonin Reuptake Inhibitors in Term Infants. Arch Pediatr Adolesc Med. 2006;160(2):173-176. Reference URL:https://jamanetwork.com/journals/jamapediatrics/fullarticle/204468