The answer is B. Various studies have found a small increase in risk for persistent pulmonary hypertension (PPHN) of the newborn as a result of SSRI exposure in the 2nd and early 3rd trimester. However, a recent large study found that the increase in risk is small in magnitude (OR greater than 1, but less than 2), and the absolute risk remains quite low (0.6%). A and D are incorrect because cardiac defects have been noted with 1st trimester, not 2nd trimester, exposure to SSRIs (though any potential increase in risk is likely very low). C and E are incorrect because SSRIs are not thought to be associated with an increase in risk for neural tube defects.

Publication reference : Huybrechts KF, Bateman BT, Palmsten K, et al. Antidepressant use late in pregnancy and risk of persistent pulmonary hypertension of the newborn. JAMA 2015; 313: 2142-51.
Reference URL: https://www.ncbi.nlm.nih.gov/pubmed/26034955